Principal Scientist/Sr. Principal Scientist, Computational Chemistry & Molecular Design

Full-time Other

Salary Band: $185,000-$240,000

Location: Downtown Boston, MA (In-Office 2-3 days/week)

Position Overview

We are seeking an exceptional computational chemist to serve as a scientific leader in molecular design across our discovery portfolio. As a member of a highly integrated team of medicinal chemists, machine learning scientists, structural biologists, biologists, and chemical biologists, you will apply and advance the full range of modern computational methods — structure- and ligand-based design, molecular dynamics, free energy perturbation (FEP), and machine-learning / generative approaches — to assess and prioritize targets, identify high-quality starting points, and drive lead optimization toward development candidates.

This is a hands-on, high-impact role on the Antares scientific track. The successful candidate will not only enable programs directly but will also help shape the computational chemistry, machine learning and...