Developing and constructing an advanced system for correlative label-free and fluorescence microscopy.

Full-time Life Scientists

You have a Master of Science degree and experience with (advanced) optical microscopy. Experience with optical modeling and microscope construction is required. An interest in pursuing the biological applications of this project is required.Optical imaging is a cornerstone of modern biological research, yet current methods face a fundamental problem: techniques that offer rich molecular-level information, such as fluorescence microscopy, require chemical labelling and struggle with long-term or non-invasive imaging, while label-free approaches like optical coherence tomography can image living tissue freely but yield signals that are difficult to interpret biologically. As a result, no existing method can simultaneously deliver non-invasive, and molecularly informative imaging of complex 3D samples such as organoids or tissue slices.In this Ph.D., the focus is set on developing a correlative imaging platform that combines fluorescence and light-scattering modalities within a single ins...